rs776746 CYP3A5
CYP3A5*1/*1 expresser. Rapid tacrolimus metabolism; higher dose needed for transplant patients.
What is rs776746?
rs776746 is a single-nucleotide polymorphism (SNP) in the CYP3A5 gene (Cytochrome P450 3A5). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs776746 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | increased | CYP3A5*1/*1 expresser. Rapid tacrolimus metabolism; higher dose needed for transplant patients. | 88% |
| CT / TC | increased | CYP3A5*1/*3 intermediate expresser. Moderately increased tacrolimus clearance. | 85% |
| CC | typical | CYP3A5*3/*3 non-expresser. Standard tacrolimus dosing. | 88% |
How common is the T allele of rs776746?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 6.0% |
|---|---|
| East Asian | 30.0% |
| African | 70.0% |
| South Asian | 35.0% |
| Admixed American | 20.0% |
| Global | 30.0% |
Which drugs have annotations for rs776746?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| nifedipine | Other, Dosage, Toxicity, Metabolism/PK, Efficacy | 3 |
| sunitinib | Other, Dosage, Toxicity, Metabolism/PK, Efficacy | 3 |
Is rs776746 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs776746 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.