IFNL3 Interferon lambda 3
IFNL3 (Interferon lambda 3): 5 variants described, covering drug response, trait, health risk.
Which IFNL3 variants does Orviva describe?
- rs11881222 Drug response imported
- Allele G is associated with increased response to peginterferon alfa-2a and ribavirin in people with Hepatitis C, Chronic as compared to allele A.
- rs12979860 Drug response imported
- IFNL3 intermediate genotype. Reduced likelihood of SVR to peginterferon-based HCV treatment. Prefer direct-acting antivirals.
- rs8099917 Drug response imported
- Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic and Hepatitis C, Chronic as compared to genotypes GG
2 further IFNL3 variants in the knowledge base have only a brief annotation and are not listed here.
See your own IFNL3 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my IFNL3 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my IFNL3 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.