rs12979860 IFNL3
IFNL3 favorable genotype. Higher likelihood of sustained virological response to peginterferon-based hepatitis C treatment.
What is rs12979860?
rs12979860 is a single-nucleotide polymorphism (SNP) in the IFNL3 gene (Interferon lambda 3). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs12979860 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | typical | IFNL3 favorable genotype. Higher likelihood of sustained virological response to peginterferon-based hepatitis C treatment. | 90% |
| CT | increased | IFNL3 intermediate genotype. Reduced likelihood of SVR to peginterferon-based HCV treatment. Prefer direct-acting antivirals. | 90% |
| TT | increased | IFNL3 unfavorable genotype. Low likelihood of SVR to peginterferon-based HCV treatment. Direct-acting antivirals strongly preferred. | 90% |
Which drugs have annotations for rs12979860?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| peginterferon alfa-2a | Efficacy, Metabolism/PK, Dosage | 1A |
| peginterferon alfa-2b | Efficacy, Metabolism/PK, Dosage | 1A |
| ribavirin | Efficacy, Metabolism/PK, Dosage | 1A |
| telaprevir | Efficacy | 1A |
Is rs12979860 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PharmGKB:1A
- Drug:peginterferon alfa-2a
- Type:Efficacy
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs12979860 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.