VKORC1 Vitamin K epoxide reductase complex subunit 1
VKORC1 (Vitamin K epoxide reductase complex subunit 1): 8 variants described, covering drug response.
Which VKORC1 variants does Orviva describe?
- rs9923231 Drug response
- VKORC1 low-dose warfarin genotype. Significantly lower warfarin dose required.
- rs61742245 Drug response imported
- Genotype AC is associated with increased dose of warfarin in people with warfarin maintenance treatment as compared to genotype CC.
- rs7294 Drug response imported
- Allele T is associated with increased dose of warfarin.
- rs9934438 Drug response imported
- Genotype AA is associated with decreased dose of acenocoumarol in children as compared to genotypes AG + GG.
4 further VKORC1 variants in the knowledge base have only a brief annotation and are not listed here.
See your own VKORC1 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my VKORC1 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my VKORC1 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.