rs7294 VKORC1
Allele T is associated with increased dose of warfarin.
What is rs7294?
rs7294 is a single-nucleotide polymorphism (SNP) in the VKORC1 gene (Vitamin K epoxide reductase complex subunit 1). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as T. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs7294 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| T | typical | Allele T is associated with increased dose of warfarin. | 90% |
| C | typical | Allele C is associated with decreased dose of warfarin as compared to allele T. | 90% |
| CT | typical | Genotype CT is associated with increased dose of warfarin as compared to genotype CC. | 90% |
| TT | typical | Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT. | 90% |
| CC | typical | Genotype CC is associated with decreased concentrations of warfarin in people with heart valve replacement as compared to genotypes CT + TT. | 90% |
Which drugs have annotations for rs7294?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| Allele T is associated with increased dose of warfarin., Allele C is associated with decreased dose of warfarin as compared to allele T., Genotype CT is associated with increased dose of warfarin as compared to genotype CC., Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT., Genotype CC is associated with decreased concentrations of warfarin in people with heart valve replacement as compared to genotypes CT + TT. |
Is rs7294 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs7294 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.