rs9934438 VKORC1
Genotype AA is associated with decreased dose of acenocoumarol in children as compared to genotypes AG + GG.
What is rs9934438?
rs9934438 is a single-nucleotide polymorphism (SNP) in the VKORC1 gene (Vitamin K epoxide reductase complex subunit 1). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs9934438 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | typical | Genotype AA is associated with decreased dose of acenocoumarol in children as compared to genotypes AG + GG. | 90% |
| A | typical | Allele A is associated with decreased dose of warfarin. | 90% |
| GG | typical | Genotype GG is associated with increased dose of warfarin in people with heart valve replacement as compared to genotypes AA + AG. | 90% |
| AG | typical | Genotype AG is associated with increased dose of warfarin in people with Atrial Fibrillation, Cardiomyopathies, heart valve replacement, Peripheral Vascular Diseases, Pulmonary Embolism and Venous Thr | 90% |
Which drugs have annotations for rs9934438?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| Genotype AA is associated with decreased dose of acenocoumarol in children as compared to genotypes AG + GG., Allele A is associated with decreased dose of warfarin., Genotype GG is associated with increased dose of warfarin in people with heart valve replacement as compared to genotypes AA + AG., Genotype AG is associated with increased dose of warfarin in people with Atrial Fibrillation, Cardiomyopathies, heart valve replacement, Peripheral Vascular Diseases, Pulmonary Embolism and Venous Thr |
Is rs9934438 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs9934438 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.