CYP2D6 Cytochrome P450 2D6

CYP2D6 (Cytochrome P450 2D6): 11 variants described, covering drug response; CPIC pharmacogenomic guidance available.

11 curated variants

CYP2D6 and medicines

CYP2D6 is a pharmacogene with CPIC guidance. Star alleles, metaboliser phenotypes and the drugs affected are on the CYP2D6 pharmacogenomics page.

Which CYP2D6 variants does Orviva describe?

rs1065852 Drug response: CYP2D6*10 or *4 variant. Reduced CYP2D6 activity; affects metabolism of codeine, tamoxifen, SSRIs, beta-blockers.
rs1135840 Drug response: CYP2D6 4180G>C (S486T) reference. Shared variant in *2 and many other haplotypes.
rs16947 Drug response: CYP2D6 2850C>T (R296C) homozygous. Shared variant in *2, *8, *11, *12, *14, *17, *29, *41 haplotypes.
rs28371706 Drug response: CYP2D6*17 homozygous (T107I). Decreased CYP2D6 function; common in African populations.
rs28371725 Drug response: CYP2D6*41 homozygous (2988G>A splicing defect). Decreased CYP2D6 function; affects codeine, tramadol, tamoxifen.
rs35742686 Drug response: CYP2D6*3 carrier (2549delA frameshift). Loss of CYP2D6 function; affects codeine, tramadol, tamoxifen metabolism.
rs3892097 Drug response: CYP2D6*4 homozygous poor metabolizer. Codeine ineffective (cannot convert to morphine). Affects tamoxifen, SSRIs, and many other drugs.
rs5030655 Drug response: CYP2D6*6 carrier (1707delT frameshift). Loss of CYP2D6 function.
rs5030865 Drug response: CYP2D6*8 homozygous (1758G>T). Loss of CYP2D6 function.
rs5030867 Drug response: CYP2D6*7 homozygous (H324P). Loss of CYP2D6 function.
rs59421388 Drug response: CYP2D6*29 homozygous (V136I). Decreased CYP2D6 function; common in African populations.

See your own CYP2D6 genotypes
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Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.