rs1065852 CYP2D6
CYP2D6*10 or *4 variant. Reduced CYP2D6 activity; affects metabolism of codeine, tamoxifen, SSRIs, beta-blockers.
What is rs1065852?
rs1065852 is a single-nucleotide polymorphism (SNP) in the CYP2D6 gene (Cytochrome P450 2D6). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs1065852 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | reduced | CYP2D6*10 or *4 variant. Reduced CYP2D6 activity; affects metabolism of codeine, tamoxifen, SSRIs, beta-blockers. | 85% |
| GA / AG | reduced | CYP2D6 intermediate metabolizer. Partially reduced drug metabolism. | 82% |
| GG | typical | Normal CYP2D6 activity. | 85% |
How common is the A allele of rs1065852?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 20.0% |
|---|---|
| East Asian | 50.0% |
| African | 12.0% |
| South Asian | 15.0% |
| Admixed American | 18.0% |
| Global | 23.0% |
Which drugs have annotations for rs1065852?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| iloperidone | Toxicity, Efficacy, Metabolism/PK | 3 |
| opioids | Toxicity, Efficacy, Metabolism/PK | 3 |
| escitalopram | Toxicity, Efficacy, Metabolism/PK | 3 |
| aripiprazole | Toxicity | 3 |
Is rs1065852 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs1065852 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.