rs28371725 CYP2D6
CYP2D6*41 homozygous (2988G>A splicing defect). Decreased CYP2D6 function; affects codeine, tramadol, tamoxifen.
What is rs28371725?
rs28371725 is a single-nucleotide polymorphism (SNP) in the CYP2D6 gene (Cytochrome P450 2D6). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs28371725 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | reduced | CYP2D6*41 homozygous (2988G>A splicing defect). Decreased CYP2D6 function; affects codeine, tramadol, tamoxifen. | 88% |
| GT / TG | reduced | CYP2D6*41 carrier. Decreased function allele. | 85% |
| GG | typical | No CYP2D6*41 variant detected. | 88% |
How common is the T allele of rs28371725?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 9.0% |
|---|---|
| East Asian | 2.0% |
| African | 4.0% |
| South Asian | 8.0% |
| Admixed American | 6.0% |
| Global | 6.0% |
Is rs28371725 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs28371725 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.