rs59421388 CYP2D6
CYP2D6*29 homozygous (V136I). Decreased CYP2D6 function; common in African populations.
What is rs59421388?
rs59421388 is a single-nucleotide polymorphism (SNP) in the CYP2D6 gene (Cytochrome P450 2D6). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs59421388 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | reduced | CYP2D6*29 homozygous (V136I). Decreased CYP2D6 function; common in African populations. | 85% |
| CT / TC | reduced | CYP2D6*29 carrier. Decreased function allele. | 80% |
| CC | typical | No CYP2D6*29 variant detected. | 85% |
How common is the T allele of rs59421388?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 0.1% |
|---|---|
| East Asian | 0.1% |
| African | 10.0% |
| South Asian | 0.5% |
| Admixed American | 2.0% |
| Global | 2.0% |
Is rs59421388 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs59421388 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.